Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL3710175 | 0.95 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| SCHEMBL8038687 | 0.93 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| SCHEMBL637250 | 0.93 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| SCHEMBL12188002 | 0.93 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Hydrogen Sulfide SCHEMBL28158135 | 0.92 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Hydrochloric Acid SCHEMBL3325847 | 0.92 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Sulfuric Acid SCHEMBL27999742 | 0.90 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Formic Acid SCHEMBL27642652 | 0.90 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Acetic Acid SCHEMBL27714845 | 0.85 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| SCHEMBL753629 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210719-A1 | O-DESMETHYLVENLAFAXINE | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-08-19 | — | — | US | disclosed |
| WO-2009009665-A2 | O-DESMETHYLVENLAFAXINE | DR. REDDY'S LABORATORIES, LTD. (IN) | 2009-01-15 | — | — | WO | disclosed |
| CN-101245021-A | Process for synthesizing 1-[2-amido-1-(4-methoxy phenyl)ethyl]cyclohexanol acetate | SHANGHAI HUASHI MEDICAL HI TEC (CN) | 2008-08-20 | — | — | CN | disclosed |
| EP-1721889-A1 | Process for the preparation of phenethylamine derivatives | Dishman Pharmaceuticals & Chemicals Ltd. (IN) | 2006-11-15 | — | — | EP | disclosed |
| WO-2006035457-A1 | A PROCESS FOR THE MANUFACTURE OF VENLAFAXINE AND INTERMEDIATES THEREOF | AMOLI ORGANICS LTD. (IN) | 2006-04-06 | — | — | WO | disclosed |
| US-20050033088-A1 | Process for the preparation of phenethylamine derivative, an intermediate of Venlafaxine hydrochloride | DR. REDDY'S LABORATORIES LIMITED | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210719-A1 | O-DESMETHYLVENLAFAXINE | SLC6A4, SLC6A2, CYP2D6 | SLC6A2 2/4885SLC6A4 1/4885SLC6A3 7/4885 |
| US-20050033088-A1 | Process for the preparation of phenethylamine derivative, an intermediate of Venlafaxine hydrochloride | COMT, PNMT, MAOA | SLC6A2 4/4885SLC6A4 10/4885SLC6A3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.