Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.89 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 6/20 | 0.50 |
| ▸ | CA9 | Q16790 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CA5A | P35218 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phloroglucinol SCHEMBL2889628 | 0.94 | BACE1 (1.00) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL30542958 | 0.94 | — | — | |
| Phloroglucinol SCHEMBL26311 | 0.94 | — | — | |
| Phloroglucinol SCHEMBL502610 | 0.89 | BACE1 (0.89) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL5495237 | 0.89 | BACE1 (0.89) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL23346245 | 0.89 | BACE1 (0.89) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL310716 | 0.89 | BACE1 (0.89) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL1913949 | 0.89 | BACE1 (0.89) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL10916023 | 0.89 | BACE1 (0.89) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL28934911 | 0.89 | BACE1 (0.89) | BACE1LCKCA12CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230123529-A1 | METHOD OF TUNING THE ELECTRONIC ENERGY LEVEL OF COVALENT ORGANIC FRAMEWORK FOR CRAFTING HIGH-RATE NA-ION BATTERY ANODE | INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IN) | 2023-04-20 | — | — | US | disclosed |