Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | PRCP | P42785 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.58 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30364176 | 0.81 | SIGMAR1 (0.77) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL12863726 | 0.79 | SIGMAR1 (0.42) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL3407261 | 0.78 | GRIN1 (0.92) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL20918712 | 0.77 | GRIN1 (0.42) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL19634059 | 0.77 | GRIN1 (0.84) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL29147700 | 0.76 | SIGMAR1 (0.44) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL28282384 | 0.75 | GRIN1 (0.88) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL19280300 | 0.74 | GRIN1 (0.44) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL9153279 | 0.73 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Rolicyclidine SCHEMBL517928 | 0.73 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230101819-A1 | SMYD Inhibitors | EPIZYME INC (US) | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230101819-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | SIGMAR1 1192/4885GRIN1 4591/4885GRIN2A 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.