Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.92 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.92 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.92 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.92 |
| ▸ | PRCP | P42785 | 3/20 | 0.92 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.92 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.92 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.92 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.92 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.92 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.92 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.92 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.92 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.92 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.89 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.89 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153279 | 0.96 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL17008793 | 0.96 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL42022 | 0.96 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Rolicyclidine SCHEMBL517928 | 0.96 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL21777 | 0.94 | OPRM1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL5166553 | 0.94 | SIGMAR1 (0.96) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL9431514 | 0.92 | SIGMAR1 (0.92) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| SCHEMBL30364176 | 0.91 | SIGMAR1 (0.77) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| SCHEMBL28282384 | 0.89 | GRIN1 (0.88) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL28296317 | 0.89 | GRIN1 (0.86) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154450-A2 | (AMPA-PAM)-NMDA RECEPTOR ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF MENTAL CONDITIONS AND DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |
| US-20220409555-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS INC (US) | 2022-12-29 | — | — | US | disclosed |
| US-11344510-B2 | Arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders | GILGAMESH PHARMACEUTICALS, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| WO-2021134086-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2021-07-01 | — | — | WO | disclosed |
| WO-2020120539-A1 | NEW PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-06-18 | — | — | WO | disclosed |
| US-8288430-B2 | Spiro(5.5)undecane derivatives | GRUNENTHAL GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| EP-2257526-B1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-12-14 | — | — | EP | disclosed |
| EP-2257526-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009118169-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344510-B2 | Arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders | HTR2C, PNMT, HTR2A | GRIN1 83/4885GRIN2A 19/4885GRIN2B 33/4885 |
| US-20220409555-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | HTR2C, PNMT, HTR2A | GRIN1 75/4885GRIN2A 14/4885GRIN2B 26/4885 |
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | OPRL1, OPRD1, OPRM1 | GRIN1 89/4885GRIN2A 157/4885GRIN2B 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.