Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 6/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18763946 | 0.90 | HTR3A (0.44) | PROKR1 | |
| SCHEMBL20135330 | 0.83 | HTR2C (0.42) | TLR9TLR8TLR7HTR2CCHRM4 | |
| SCHEMBL16760114 | 0.81 | HTR2A (0.43) | PROKR1HTR2CSLC6A2SLC6A4 | |
| SCHEMBL25723470 | 0.78 | CHRM4 (0.40) | TLR9TLR8TLR7HTR2CCHRM4 | |
| SCHEMBL30899636 | 0.77 | CHRNB2 (0.40) | HTR2CSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL25275850 | 0.76 | CHRM4 (0.39) | TLR9TLR8TLR7HTR2CCHRM4 | |
| SCHEMBL31533212 | 0.76 | EP300 (0.38) | TLR9TLR8TLR7HTR2CCHRM4 | |
| SCHEMBL29287756 | 0.76 | EP300 (0.38) | TLR9TLR8TLR7HTR2CCHRM4 | |
| SCHEMBL31702071 | 0.72 | PLAT (0.41) | PROKR1 | |
| SCHEMBL18741830 | 0.71 | HTR3A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405051-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| CN-118076604-A | Pyrazolo [3,4-b ] pyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2024-05-24 | — | — | CN | disclosed |
| WO-2023046806-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |