Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.41 |
| ▸ | MTOR | P42345 | 9/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26079035 | 0.88 | PIK3CA (0.49) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL30366394 | 0.83 | ALDH1A1 (0.48) | PIK3CAMTORPIK3CDKDM4EALDH1A1 | |
| SCHEMBL26079034 | 0.83 | ALDH1A1 (0.48) | PIK3CAMTORPIK3CDKDM4EALDH1A1 | |
| SCHEMBL19849051 | 0.80 | SMN1; SMN2 (0.41) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL30366515 | 0.80 | KDM4E (0.41) | PIK3CAMTORPIK3CDPIK3CBKDM4E | |
| SCHEMBL26071916 | 0.80 | KDM4E (0.41) | PIK3CAMTORPIK3CDPIK3CBKDM4E | |
| SCHEMBL29788273 | 0.80 | PIK3CA (0.40) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL190265 | 0.80 | PIK3CA (0.40) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL1181308 | 0.78 | SMN1; SMN2 (0.40) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL1180546 | 0.77 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312577-A1 | DUAL KINASE-BROMODOMAIN INHIBITORS | MONASH UNIVERSITY (AU) | 2023-10-05 | — | — | US | disclosed |
| EP-4165045-A1 | DUAL KINASE-BROMODOMAIN INHIBITORS | Monash University (AU) | 2023-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312577-A1 | DUAL KINASE-BROMODOMAIN INHIBITORS | MAP2K2, BRPF3, BRDT | PIK3CA 574/4885MTOR 679/4885PIK3CD 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.