SCHEMBL30367450

SCHEMBL30367450

CC(C)C(=O)N1CCC(c2cc(-c3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccccn5)c4=O)cc3)c3c(N)nccn23)CC1

nearest known ligand 0.81

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TYRO3 Q06418 8/20 0.81
▸ MERTK Q12866 13/20 0.70
▸ AXL P30530 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19398147 0.89 TYRO3 (1.00) TYRO3MERTKAXL
SCHEMBL30366999 0.87 TYRO3 (0.67) TYRO3MERTKAXL
Maleic Acid SCHEMBL29526181 0.86 TYRO3 (0.93) TYRO3MERTKAXL
SCHEMBL30367554 0.84 TYRO3 (0.72) TYRO3MERTKAXL
SCHEMBL24371883 0.84 TYRO3 (0.85) TYRO3MERTKAXL
SCHEMBL20869661 0.83 TYRO3 (0.70) TYRO3MERTKAXL
SCHEMBL19398176 0.82 MERTK (1.00) TYRO3MERTKAXL
SCHEMBL23965835 0.82 TYRO3 (0.87) TYRO3MERTK
SCHEMBL29052448 0.82 TYRO3 (0.72) TYRO3MERTKAXL
SCHEMBL23791677 0.81 TYRO3 (0.68) TYRO3MERTKAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116437918-A Pyrazolopyridine compounds as TAM inhibitors 上海德琪医药科技有限公司 2023-07-14 — — CN disclosed
WO-2023051464-A1 PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS SHANGHAI ANTENGENE CORPORATION LIMITED (CN) 2023-04-06 — — WO disclosed
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