Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 6/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23888024 | 1.00 | NR4A2 (0.53) | NR4A2SRD5A2HDAC1HDAC2MAOB | |
| SCHEMBL10784972 | 0.82 | SRD5A2 (0.77) | NR4A2SRD5A2MAOBPARP10KMT2A | |
| SCHEMBL5377638 | 0.81 | SRD5A2 (0.58) | NR4A2SRD5A2MAOBPARP10KMT2A | |
| SCHEMBL7914507 | 0.81 | SRD5A2 (0.66) | NR4A2SRD5A2MAOBPARP10PTGES | |
| SCHEMBL5495792 | 0.81 | MAOB (0.60) | NR4A2SRD5A2MAOBPARP10KMT2A | |
| SCHEMBL162815 | 0.80 | PARP10 (0.60) | NR4A2MAOBPARP10KMT2AMEN1 | |
| SCHEMBL401103 | 0.80 | SRD5A2 (0.59) | NR4A2SRD5A2MAOBPARP10KMT2A | |
| SCHEMBL4979325 | 0.79 | TUBB4A (0.50) | MAOB | |
| SCHEMBL2686883 | 0.79 | PTGES (0.70) | NR4A2SRD5A2MAOBPARP10KMT2A | |
| Hydrochloric Acid SCHEMBL7249802 | 0.78 | MAOB (0.72) | MAOBPARP10MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697969-A | 7-or 8-hydroxy-isoquinoline and 7-or 8-hydroxy-quinoline derivatives as alpha-1 antitrypsin modulators for the treatment of alpha-1 antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-03 | — | — | CN | disclosed |