Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 16/20 | 0.40 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887779 | 1.00 | ESR1 (0.40) | ESR1ESR2ESRRBESRRATLR8 | |
| SCHEMBL25544237 | 0.86 | PTGS2 (0.36) | PTGS1PTGS2 | |
| SCHEMBL30120996 | 0.82 | KDM4E (0.39) | TLR8PTGS2 | |
| SCHEMBL23887869 | 0.82 | KDM4E (0.39) | TLR8PTGS2 | |
| SCHEMBL30121049 | 0.80 | PPARD (0.37) | — | |
| SCHEMBL23887694 | 0.80 | PPARD (0.37) | — | |
| SCHEMBL23887781 | 0.77 | ENPP3 (0.41) | — | |
| SCHEMBL23895771 | 0.75 | GCGR (0.37) | ESR1ESR2TLR8PTGS2 | |
| SCHEMBL25544512 | 0.73 | GCGR (0.34) | PTGS1PTGS2 | |
| SCHEMBL23887876 | 0.71 | ESR1 (0.35) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697969-A | 7-or 8-hydroxy-isoquinoline and 7-or 8-hydroxy-quinoline derivatives as alpha-1 antitrypsin modulators for the treatment of alpha-1 antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-03 | — | — | CN | disclosed |