Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26326289 | 1.00 | HTR2A (0.36) | HTR2AHTR2CHTR2BGSK3BCDK5 | |
| SCHEMBL29317013 | 0.74 | FGFR1 (0.37) | GSK3BCDK5KDRCHEK1AURKA | |
| SCHEMBL30057144 | 0.74 | FGFR1 (0.37) | GSK3BCDK5KDRCHEK1AURKA | |
| SCHEMBL27167139 | 0.72 | CDK5 (0.36) | HTR2AHTR2CHTR2BGSK3BCDK5 | |
| SCHEMBL15872980 | 0.70 | HTR2A (0.39) | HTR2AHTR2CHTR2BTDP1POLB | |
| SCHEMBL29600231 | 0.70 | HTR2A (0.39) | HTR2AHTR2CHTR2BTDP1POLB | |
| SCHEMBL24192115 | 0.67 | CHEK1 (0.39) | GSK3BCDK5KDRCHEK1AURKA | |
| SCHEMBL580431 | 0.65 | CDK5 (0.47) | GSK3BCDK5KDRCHEK1AURKA | |
| SCHEMBL1699143 | 0.64 | MEN1 (0.44) | GSK3BCDK5KDRMAP4K4ABL1 | |
| SCHEMBL31032294 | 0.63 | CDK5 (0.48) | GSK3BCDK5KDRCHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4175719-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2023-05-10 | — | — | EP | disclosed |