Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15872980 | 1.00 | HTR2A (0.39) | HTR2AHTR2CHTR2BALDH1A1CYP1A2 | |
| SCHEMBL15872863 | 0.80 | GPR35 (0.36) | ALDH1A1CYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL15883622 | 0.80 | ALDH1A1 (0.38) | ALDH1A1CYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL29599945 | 0.78 | PIN1 (0.35) | ALDH1A1CYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL15872798 | 0.78 | PIN1 (0.35) | ALDH1A1CYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL19059991 | 0.74 | CDK2 (0.41) | ALDH1A1CYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL18399566 | 0.74 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL19059616 | 0.74 | — | — | |
| SCHEMBL17266512 | 0.71 | AXL (0.35) | POLBACHEGABRA1GABRG2GABRB3 | |
| SCHEMBL26326289 | 0.70 | HTR2A (0.36) | HTR2AHTR2CHTR2BALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4186897-A1 | PYRIDINECARBOXAMIDE COMPOUND USEFUL AS PIM KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2023-05-31 | — | — | EP | disclosed |
| CN-108715590-B | Thiazolecarboxamide and picolinamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2022-03-08 | — | — | CN | disclosed |