Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22075942 | 1.00 | TSHR (0.56) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL29040439 | 0.90 | MAPT (0.52) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL30457845 | 0.90 | MAPT (0.52) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL30457737 | 0.89 | PDK1 (0.64) | TSHRHSD17B10ALOX15MAPTTP53 | |
| Hydrochloric Acid SCHEMBL30457727 | 0.88 | PDK1 (0.62) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL22075949 | 0.88 | TSHR (0.56) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL25415661 | 0.87 | TSHR (0.57) | TSHRHSD17B10MAPTTP53NPC1 | |
| SCHEMBL31536432 | 0.87 | TSHR (0.57) | TSHRHSD17B10MAPTTP53NPC1 | |
| SCHEMBL23499609 | 0.87 | ALDH1A1 (0.55) | TSHRHSD17B10ALOX15MAPTTP53 | |
| Sulfuric Acid SCHEMBL30458029 | 0.86 | PDK1 (0.60) | TSHRHSD17B10MAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426700-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | Merck Patent GmbH (DE) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023078813-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | MERCK PATENT GMBH (DE) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081452-A1 | SMALL-MOLECULE DEGRADERS OF CDK8 AND CDK19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2023-05-11 | — | — | WO | disclosed |