Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | EIF4E | P06730 | 1/20 | 0.51 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036977 | 1.00 | APEX1 (0.59) | APEX1HIF1ANSTAT3MEN1KMT2A | |
| SCHEMBL3033780 | 0.89 | STAT3 (0.64) | APEX1HIF1ANSTAT3MEN1KMT2A | |
| SCHEMBL3033782 | 0.89 | STAT3 (0.64) | APEX1HIF1ANSTAT3MEN1KMT2A | |
| SCHEMBL3036197 | 0.87 | MAP3K5 (0.62) | APEX1MEN1KMT2ATDP1MCL1 | |
| SCHEMBL3036194 | 0.87 | MAP3K5 (0.62) | APEX1MEN1KMT2ATDP1MCL1 | |
| SCHEMBL3040354 | 0.85 | MAP3K5 (0.61) | APEX1STAT3MEN1KMT2ATDP1 | |
| SCHEMBL3040356 | 0.85 | MAP3K5 (0.61) | APEX1STAT3MEN1KMT2ATDP1 | |
| SCHEMBL13220182 | 0.81 | MAPT (0.67) | APEX1STAT3MEN1KMT2ATDP1 | |
| SCHEMBL20339299 | 0.77 | STAT3 (0.74) | APEX1HIF1ANSTAT3MEN1KMT2A | |
| SCHEMBL20339302 | 0.77 | STAT3 (0.74) | APEX1HIF1ANSTAT3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338465-B2 | Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100210577-A1 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | CORNELL RESEARCH FOUNDATION, INC. | 2010-08-19 | — | — | US | disclosed |
| WO-2008005651-A2 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | DECODE CHEMISTRY, INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210577-A1 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | RARG, SDHA, RARS2 | APEX1 2575/4885HIF1AN 388/4885STAT3 3058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.