Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | LPL | P06858 | 6/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25177449 | 1.00 | JAK2 (0.39) | JAK2BTKLPLLIPGEGFR | |
| SCHEMBL25606836 | 0.86 | EGFR (0.39) | JAK2BTKLPLLIPGEGFR | |
| SCHEMBL31082147 | 0.83 | LPL (0.47) | JAK2BTKLPLLIPGIRAK4 | |
| SCHEMBL3708705 | 0.83 | LPL (0.47) | JAK2BTKLPLLIPGIRAK4 | |
| SCHEMBL29634815 | 0.83 | LPL (0.42) | JAK2BTKLPLLIPGIRAK4 | |
| SCHEMBL30876507 | 0.83 | LPL (0.42) | JAK2BTKLPLLIPGIRAK4 | |
| SCHEMBL22555255 | 0.83 | LPL (0.42) | JAK2BTKLPLLIPG | |
| SCHEMBL23043319 | 0.83 | LPL (0.42) | JAK2BTKLPLLIPGIRAK4 | |
| SCHEMBL30065387 | 0.83 | LPL (0.42) | JAK2BTKLPLLIPG | |
| SCHEMBL26622036 | 0.82 | LPL (0.40) | JAK2BTKLPLLIPGEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426695-A1 | KRAS G12C INHIBITORS | Frontier Medicines Corporation (US) | 2024-09-11 | — | — | EP | disclosed |
| EP-4415824-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023081840-A1 | KRAS G12C INHIBITORS | FRONTIER MEDICINES CORPORATION (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023064857-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-04-20 | — | — | WO | disclosed |