Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RPA1 | P27694 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946316 | 1.00 | MEN1 (0.57) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL3063301 | 0.89 | MEN1 (0.54) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL13078465 | 0.87 | MEN1 (0.56) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL13044122 | 0.84 | MEN1 (0.53) | MEN1KMT2AHTTSMN1; SMN2KDM4E | |
| SCHEMBL4944264 | 0.82 | SLC9A1 (0.71) | — | |
| SCHEMBL12670456 | 0.80 | ALDH1A1 (0.68) | MEN1KMT2AALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4944262 | 0.80 | MEN1 (0.55) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL14472215 | 0.78 | MEN1 (0.51) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6355620 | 0.78 | MEN1 (0.51) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2135901 | 0.77 | MEN1 (0.50) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-A1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | Mission Therapeutics Limited (GB) | 2023-04-05 | — | — | EP | disclosed |