Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.78 |
| ▸ | AURKA | O14965 | 1/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | PRKACA | P17612 | 2/20 | 0.62 |
| ▸ | PRKX | P51817 | 2/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | GSK3A | P49840 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036981 | 0.91 | AURKA (0.64) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL3035661 | 0.89 | MMP13 (0.76) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL5332068 | 0.88 | MMP13 (1.00) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL31061610 | 0.88 | MMP13 (1.00) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL9416645 | 0.88 | MMP13 (0.94) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL3038715 | 0.86 | MMP13 (0.72) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL12496869 | 0.85 | AURKA (0.72) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL16297611 | 0.85 | MMP13 (0.69) | MMP13HPGDLMNAROCK2HDAC1 | |
| SCHEMBL7134254 | 0.84 | MMP13 (0.86) | MMP13AURKAHPGDLMNAROCK2 | |
| SCHEMBL5332456 | 0.83 | MMP13 (0.89) | MMP13AURKAHPGDLMNAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | claimed |
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | BRDT, AADAC, ACIN1 | MMP13 1790/4885AURKA 2957/4885HPGD 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.