Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA4 | P22748 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302686 | 0.92 | LMNA (0.49) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL1723202 | 0.90 | FNTA (0.45) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL304021 | 0.85 | PROKR1 (0.49) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL303569 | 0.85 | LMNA (0.46) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL303692 | 0.84 | LMNA (0.66) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL1710991 | 0.83 | LMNA (0.47) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL1722406 | 0.82 | LMNA (0.58) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL302109 | 0.82 | LMNA (0.47) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL3275416 | 0.81 | RAB9A (0.52) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL1722401 | 0.81 | KMT2A (0.55) | LMNAKMT2AMEN1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500834-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | claimed |
| WO-2010023445-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |