Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19585576 | 0.81 | CRBN (0.51) | CRBNDDB1 | |
| SCHEMBL19585878 | 0.79 | CRBN (0.58) | CRBNDDB1KDM4E | |
| SCHEMBL19586642 | 0.79 | CRBN (0.58) | CRBNDDB1KDM4E | |
| SCHEMBL20812027 | 0.78 | CRBN (0.51) | CRBNSMN1; SMN2KMT2ADDB1PTGDR2 | |
| SCHEMBL30493456 | 0.75 | CRBN (0.53) | CRBNDDB1 | |
| SCHEMBL30493243 | 0.75 | CRBN (0.47) | CRBNDDB1 | |
| SCHEMBL23589798 | 0.75 | CRBN (0.41) | CRBNDDB1ALDH1A1TDP1 | |
| SCHEMBL23589848 | 0.75 | CRBN (0.41) | CRBNDDB1ALDH1A1TDP1 | |
| SCHEMBL30135998 | 0.74 | CRBN (0.65) | CRBNPOLBLMNADDB1KDM4E | |
| SCHEMBL31068534 | 0.74 | DDB1 (0.54) | CRBNDDB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168407-A1 | BRAF DEGRADERS | C4 Therapeutics, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |