Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596393 | 1.00 | MITF (0.57) | MITFRAB9AMAPTGAAALDH1A1 | |
| SCHEMBL2475219 | 0.87 | RAB9A (0.56) | MITFRAB9AMAPTGAAALDH1A1 | |
| SCHEMBL2479527 | 0.85 | JAK3 (0.53) | MAPTGAAKDM4EJAK3IRAK4 | |
| SCHEMBL12456545 | 0.84 | JAK3 (0.52) | MITFMAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL2479053 | 0.83 | KDM4E (0.51) | RAB9AMAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL2482122 | 0.83 | RPS6KB1 (0.52) | MAPTGAAKDM4EJAK3IRAK4 | |
| SCHEMBL12367217 | 0.82 | RAB9A (0.49) | MITFRAB9AMAPTGAAALDH1A1 | |
| SCHEMBL2480282 | 0.82 | JAK3 (0.67) | KDM4EATMJAK3IRAK4JAK2 | |
| SCHEMBL12280211 | 0.81 | CDC7 (0.53) | KDM4ECDK5CDK5R1JAK3IRAK4 | |
| SCHEMBL2483572 | 0.80 | RPS6KB1 (0.54) | MAPTGAASMN1; SMN2KDM4ECDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |