Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612223 | 0.80 | PIK3CD (0.43) | TSHRHTTALDH1A1KDM4EHPGD | |
| SCHEMBL303621 | 0.76 | ALDH1A1 (0.50) | HTTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL944673 | 0.70 | GRM5 (0.40) | TSHRALDH1A1MAP2K1GSK3B | |
| SCHEMBL2072823 | 0.70 | ATAD2 (0.68) | ATAD2TSHRHTTHIF1AALDH1A1 | |
| SCHEMBL303321 | 0.70 | ATAD2 (1.00) | ATAD2TSHRHTTHIF1AALDH1A1 | |
| SCHEMBL2716578 | 0.68 | ATAD2 (0.43) | ATAD2TSHRHTTHIF1AALDH1A1 | |
| SCHEMBL12415755 | 0.68 | ATAD2 (0.65) | ATAD2TSHRHTTHIF1AALDH1A1 | |
| SCHEMBL504084 | 0.67 | PIK3CD (0.70) | ATAD2TSHRHTTHIF1AALDH1A1 | |
| SCHEMBL2472341 | 0.65 | ATAD2 (0.52) | ATAD2TSHRHTTHIF1AALDH1A1 | |
| SCHEMBL2714345 | 0.65 | GRM5 (0.45) | ATAD2TSHRHTTHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093238-B2 | Fused thiazole derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2012-01-10 | — | — | US | disclosed |
| US-20100069361-A1 | Fused Thiazole Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-03-18 | — | — | US | disclosed |
| EP-2076512-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008044022-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069361-A1 | Fused Thiazole Derivatives as Kinase Inhibitors | JAK1, MTOR, MOK | ATAD2 1689/4885TSHR 1930/4885HTT 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.