SCHEMBL30380997

SCHEMBL30380997

COc1cc2cc(B(O)O)n(C(=O)OC(C)(C)C)c2cc1OC

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 1/20 0.36
NR1H2 P55055 8/20 0.36
PDE4B Q07343 2/20 0.35
CA12 O43570 1/20 0.34
CA9 Q16790 1/20 0.34
CTSL P07711 1/20 0.34
MTNR1A P48039 3/20 0.33
MTNR1B P49286 3/20 0.33
EHMT2 Q96KQ7 1/20 0.32
PDE4A P27815 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32
NR1H3 Q13133 1/20 0.32
SRD5A1 P18405 1/20 0.32
SRD5A2 P31213 1/20 0.32
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24076617 1.00 STING1 (0.36) STING1NR1H2PDE4BCA12CA9
SCHEMBL1551648 0.90 SUV39H2 (0.37) NR1H2
SCHEMBL25787027 0.83 NR1H2 (0.35) NR1H2CA12CA9NR1H3
SCHEMBL17422746 0.82 NR1H2 (0.34) NR1H2CA12CA9NR1H3
SCHEMBL29954465 0.82 AURKA (0.35) NR1H2CA12CA9NR1H3
SCHEMBL29955030 0.82 NR1H2 (0.46) NR1H2CA12CA9KDM4E
SCHEMBL30381658 0.82 STING1 (0.35) STING1NR1H2PDE4BCTSLMTNR1A
SCHEMBL29953334 0.82 NR1H2 (0.45) NR1H2CA12CA9MTNR1AMTNR1B
SCHEMBL513258 0.82 NR1H2 (0.45) NR1H2CA12CA9MTNR1AMTNR1B
SCHEMBL1497620 0.82 NR1H2 (0.46) NR1H2CA12CA9KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116057053-B 5-Membered heteroaryl derivatives containing at least one N and pharmaceutical compositions containing the same as active ingredient for preventing or treating mental disorders 特立尼奥公司 2024-12-31 CN disclosed
CN-116057053-A 5-membered heteroaryl derivatives containing at least one N and pharmaceutical compositions containing the same as active ingredient for preventing or treating mental disorders 大邱庆北尖端医疗产业振兴财团 2023-05-02 CN disclosed