SCHEMBL30383699

SCHEMBL30383699

COc1ccc(/C=C/C(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1O

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 9/20 0.77
▸ MAPT P10636 7/20 0.77
▸ KMT2A Q03164 7/20 0.77
▸ MEN1 O00255 5/20 0.77
▸ POLB P06746 4/20 0.77
▸ GAA P10253 4/20 0.77
▸ HPGD P15428 4/20 0.77
▸ KDM4E B2RXH2 4/20 0.77
▸ LMNA P02545 3/20 0.77
▸ MAPK1 P28482 3/20 0.77
▸ USP2 O75604 2/20 0.77
▸ HTT P42858 2/20 0.77
▸ JAK2 O60674 1/20 0.77
▸ THRB P10828 1/20 0.77
▸ ALOX12 P18054 1/20 0.77
▸ L3MBTL1 Q9Y468 1/20 0.77
▸ NPSR1 Q6W5P4 1/20 0.59
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ TUBB4A P04350 1/20 0.56
▸ TUBB P07437 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25202505 1.00 ALDH1A1 (0.77) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL30382769 1.00 ALDH1A1 (0.77) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL25201964 1.00 ALDH1A1 (0.77) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL25197128 0.99 ALDH1A1 (0.74) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL31233324 0.99 ALDH1A1 (0.74) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL25235112 0.99 ALDH1A1 (0.74) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL25205645 0.92 ALDH1A1 (0.77) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL30383832 0.90 ALDH1A1 (0.61) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL25199729 0.90 ALDH1A1 (0.61) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL25216325 0.87 MAPT (1.00) ALDH1A1MAPTKMT2AMEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed
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