Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3038848 | 0.85 | HDAC6 (0.61) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3025457 | 0.78 | HDAC6 (0.91) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL6386658 | 0.77 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL29818213 | 0.74 | LMNA (0.57) | HDAC6HDAC8HDAC2USP2ALDH1A1 | |
| SCHEMBL31324434 | 0.73 | CA1 (0.63) | USP2ALDH1A1HTTNAMPTROCK2 | |
| SCHEMBL25060935 | 0.73 | HDAC1 (0.75) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL6570908 | 0.73 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3031939 | 0.72 | NPC1 (0.80) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL5943942 | 0.71 | HDAC6 (0.76) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3028316 | 0.71 | HDAC1 (0.71) | HDAC6HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | claimed |
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | disclosed |
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | BRDT, AADAC, ACIN1 | HDAC6 31/4885HDAC1 5/4885HDAC8 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.