Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FOS | P01100 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096047 | 1.00 | POLB (0.48) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL26930705 | 0.89 | POLB (0.58) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2222366 | 0.85 | MEN1 (0.60) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL22056715 | 0.81 | ALDH1A1 (0.46) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5824244 | 0.80 | ALDH1A1 (0.47) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL19100943 | 0.80 | ALDH1A1 (0.51) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2221978 | 0.80 | AHR (0.55) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5211841 | 0.78 | MEN1 (0.47) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3518634 | 0.78 | ALDH1A1 (0.46) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7563419 | 0.78 | SMN1; SMN2 (0.49) | ALDH1A1MAPTLMNANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161928-A2 | AMINO-PYRIMIDINE CYCLO-AMIDES | F. Hoffmann-La Roche AG (CH) | 2023-04-12 | — | — | EP | disclosed |