Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.41 |
| ▸ | MGMT | P16455 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30391887 | 0.94 | MMP13 (0.45) | LMNASMN1; SMN2TGM2MAOBMMP13 | |
| SCHEMBL30891341 | 0.92 | MAOB (0.40) | LMNASMN1; SMN2TGM2MAOBMMP13 | |
| SCHEMBL25243911 | 0.91 | MMP13 (0.44) | MAOBMMP13LGALS8MGMTSYNJ2 | |
| SCHEMBL29454860 | 0.91 | MMP13 (0.44) | MAOBMMP13LGALS8MGMTSYNJ2 | |
| SCHEMBL22750141 | 0.91 | FOLH1 (0.49) | TGM2 | |
| SCHEMBL30891325 | 0.91 | HTT (0.46) | LMNASMN1; SMN2TGM2MAOBMMP13 | |
| SCHEMBL30391620 | 0.91 | HTT (0.46) | LMNASMN1; SMN2TGM2MAOBMMP13 | |
| SCHEMBL30661931 | 0.90 | MMP13 (0.40) | TGM2MAOBMMP13HTTLGALS8 | |
| SCHEMBL30891318 | 0.90 | MMP13 (0.40) | TGM2MAOBMMP13HTTLGALS8 | |
| SCHEMBL30391836 | 0.90 | HTT (0.39) | LMNASMN1; SMN2TGM2MAOBMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436610-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES | Merck Sharp & Dohme LLC (US) | 2024-10-02 | — | — | EP | disclosed |
| WO-2023091441-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | WO | disclosed |