Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.66 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 5/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659299 | 0.79 | PARP1 (1.00) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL29964360 | 0.79 | PARP1 (1.00) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL578200 | 0.79 | PARP1 (0.66) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL8204538 | 0.76 | PARP1 (0.60) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL31523640 | 0.76 | PARP1 (0.60) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL6979682 | 0.76 | PARP1 (0.65) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL17298073 | 0.76 | PARP1 (0.65) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL3126112 | 0.76 | PARP1 (0.60) | PARP1TNKSTNKS2TYMSMMP13 | |
| SCHEMBL18076621 | 0.74 | PARP1 (0.59) | PARP1TNKSTNKS2TYMSPOLB | |
| SCHEMBL175103 | 0.74 | PARP1 (0.51) | PARP1TNKSTNKS2TYMSMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096710-A | 4-oxo-3, 4-dihydroquinazolinone compounds for the treatment of BRAF related diseases and disorders | 阿雷生物药品公司 | 2023-05-09 | — | — | CN | disclosed |