Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.58 |
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126112 | 0.84 | PARP1 (0.60) | PARP1TNKS2TNKSMMP13TYMS | |
| SCHEMBL31523640 | 0.84 | PARP1 (0.60) | PARP1TNKS2TNKSMMP13TYMS | |
| SCHEMBL28307043 | 0.84 | PARP1 (0.57) | PARP1TNKS2TNKSPARP2 | |
| SCHEMBL19104680 | 0.84 | PARP1 (0.60) | PARP1TNKS2TNKSMMP13TYMS | |
| SCHEMBL28279923 | 0.81 | TNKS2 (0.58) | PARP1TNKS2ACVR1DDAH1ADORA3 | |
| SCHEMBL2659299 | 0.79 | PARP1 (1.00) | PARP1TNKS2TNKSACVR1MMP13 | |
| SCHEMBL29964360 | 0.79 | PARP1 (1.00) | PARP1TNKS2TNKSACVR1MMP13 | |
| SCHEMBL20339497 | 0.79 | PARP1 (0.64) | PARP1TNKS2TNKSPARP2KDM4E | |
| SCHEMBL29902989 | 0.79 | PARP1 (0.64) | PARP1TNKS2TNKSPARP2KDM4E | |
| SCHEMBL23073647 | 0.78 | MAPT (0.61) | PARP1L3MBTL1PARP2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384731-B | Method for preparing quinazolinone from enol | 南京理工大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-109384731-A | A method of quinazolinone is prepared by enol | 南京理工大学 | 2019-02-26 | — | — | CN | disclosed |
| US-20170197958-A1 | AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2017-07-13 | — | — | US | disclosed |
| WO-2015184011-A2 | AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197958-A1 | AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF | APLNR, AGTR1, AGTR2 | PARP1 4526/4885TNKS2 4481/4885TNKS 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.