Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 5/20 | 0.36 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | GLI1 | P08151 | 1/20 | 0.34 |
| ▸ | GLI2 | P10070 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21436497 | 0.84 | THRB (0.42) | KDRCSF1RTHRBPARP1MAP3K9 | |
| SCHEMBL3044217 | 0.79 | KDR (0.39) | KDRCSF1RTHRBPARP1MAP3K9 | |
| SCHEMBL3041897 | 0.78 | PIM1 (0.49) | KDRCSF1RTHRBPARP1MAP3K9 | |
| SCHEMBL18863294 | 0.78 | ADORA2A (0.41) | KDRCSF1RTHRBPARP1MAP3K9 | |
| SCHEMBL2527674 | 0.78 | KDR (0.38) | KDRCSF1RTHRBPARP1MAP3K9 | |
| SCHEMBL3039244 | 0.78 | PARP1 (0.36) | KDRPARP1MAP3K9MAP3K11PARP10 | |
| SCHEMBL18170563 | 0.77 | KDR (0.61) | KDRCSF1RMAP3K9MAP3K11PRKCD | |
| SCHEMBL22663482 | 0.75 | CSF1R (0.42) | KDRCSF1RPARP1MAP3K9MAP3K11 | |
| SCHEMBL22663433 | 0.75 | CSF1R (0.46) | KDRCSF1RPARP1MAP3K9MAP3K11 | |
| SCHEMBL17269693 | 0.74 | PIM1 (0.49) | KDRPARP1MAP3K9MAP3K11PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731953-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| WO-2022268176-A1 | STEROID COMPOUND, AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 江苏先声药业有限公司 | 2022-12-29 | — | — | WO | disclosed |
| EP-3738961-B1 | HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF | MEDSHINE DISCOVERY INC (CN) | 2022-08-31 | — | — | EP | disclosed |
| US-11384065-B2 | Heterocyclic compound as CSF-1R inhibitor and use thereof | MEDSHINE DISCOVERY INC. (CN) | 2022-07-12 | — | — | US | disclosed |
| US-20210107894-A1 | HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2021-04-15 | — | — | US | disclosed |
| EP-3738961-A1 | HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF | Medshine Discovery Inc. (CN) | 2020-11-18 | — | — | EP | disclosed |
| US-7745641-B2 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | NR4A1, NR5A2, PRMT8 | KDR 3226/4885CSF1R 1739/4885THRB 1098/4885 |
| US-11731953-B2 | Methods and compounds for restoring mutant p53 function | TP53, TP53BP1, HRAS | KDR 3104/4885CSF1R 3924/4885THRB 2094/4885 |
| US-11384065-B2 | Heterocyclic compound as CSF-1R inhibitor and use thereof | CSF1R, CSF3R, IL1RN | KDR 907/4885CSF1R 1/4885THRB 2338/4885 |
| US-20210107894-A1 | HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF | CSF1R, CSF3R, IL1RN | KDR 907/4885CSF1R 1/4885THRB 2338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.