Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25209667 | 1.00 | GSK3A (0.42) | GSK3AGSK3BLRRK2PTK2TRPV1 | |
| SCHEMBL25210271 | 0.77 | GSK3A (0.43) | GSK3AGSK3BLRRK2KDRKIT | |
| SCHEMBL30396166 | 0.77 | GSK3A (0.43) | GSK3AGSK3BLRRK2KDRKIT | |
| SCHEMBL16821995 | 0.71 | PRKCQ (0.44) | LRRK2PTK2KDRKCNH2PTK2B | |
| SCHEMBL28115998 | 0.71 | PRKCQ (0.44) | LRRK2PTK2KDRKCNH2PTK2B | |
| SCHEMBL24087394 | 0.70 | SDHB (0.39) | LRRK2CDK1CDK4CCNB1CCNE1 | |
| SCHEMBL20555399 | 0.68 | SMN1; SMN2 (0.33) | LRRK2TRPV1CDK1CDK4CCNB1 | |
| SCHEMBL29141591 | 0.68 | TLR9 (0.39) | LRRK2CDK1CDK2KDRTLR8 | |
| SCHEMBL20555153 | 0.66 | TLR8 (0.42) | LRRK2PTK2CCNE1CDK2KDR | |
| SCHEMBL25243394 | 0.65 | KDR (0.44) | LRRK2CDK1CDK4CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |