Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.33 |
| ▸ | ULK1 | O75385 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30396166 | 1.00 | GSK3A (0.43) | GSK3AGSK3BRXFP1AURKALRRK2 | |
| SCHEMBL25525067 | 0.85 | RXFP1 (0.36) | GSK3AGSK3BRXFP1AURKALRRK2 | |
| SCHEMBL30396196 | 0.77 | GSK3A (0.42) | GSK3AGSK3BLRRK2ULK1KDR | |
| SCHEMBL25209667 | 0.77 | GSK3A (0.42) | GSK3AGSK3BLRRK2ULK1KDR | |
| SCHEMBL16835308 | 0.70 | PRKCQ (0.45) | ULK1KDRAURKBKITFLT3 | |
| SCHEMBL16822075 | 0.70 | PRKCQ (0.45) | ULK1KDRAURKBKITFLT3 | |
| SCHEMBL16835307 | 0.70 | PRKCQ (0.45) | ULK1KDRAURKBKITFLT3 | |
| SCHEMBL25528049 | 0.70 | ALDH1A1 (0.41) | LRRK2ULK1FLT3 | |
| SCHEMBL25201215 | 0.69 | ULK1 (0.47) | LRRK2ULK1KITFLT3 | |
| SCHEMBL25521616 | 0.69 | RXFP1 (0.40) | RXFP1AURKAKDRAURKBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |