Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25262847 | 1.00 | SOS1 (0.37) | SOS1CACNA1BCACNA1CCACNA1GCFTR | |
| SCHEMBL23032506 | 0.84 | MEN1 (0.38) | SOS1CACNA1BCACNA1CCACNA1GHDAC1 | |
| SCHEMBL23032507 | 0.82 | POLQ (0.38) | SOS1CACNA1BCACNA1CCACNA1GHDAC1 | |
| SCHEMBL21031816 | 0.82 | CACNA1G (0.35) | SOS1CACNA1BCACNA1CCACNA1GHDAC1 | |
| SCHEMBL21031817 | 0.81 | CACNA1G (0.34) | SOS1CACNA1BCACNA1CCACNA1GHDAC1 | |
| SCHEMBL30799546 | 0.76 | SOS1 (0.36) | SOS1HDAC1HDAC8HDAC6BACE1 | |
| SCHEMBL404990 | 0.76 | BACE1 (0.39) | SOS1CACNA1BCACNA1CCACNA1GCFTR | |
| SCHEMBL25256413 | 0.74 | HDAC1 (0.31) | CACNA1BCACNA1CCACNA1GHDAC1HDAC8 | |
| SCHEMBL31038485 | 0.74 | HDAC1 (0.31) | CACNA1BCACNA1CCACNA1GHDAC1HDAC8 | |
| SCHEMBL31038421 | 0.74 | CFTR (0.40) | CFTRHDAC1HDAC8HDAC6BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118451068-A | Tri-fused ring derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-08-06 | — | — | CN | disclosed |
| WO-2023125877-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |
| CN-116171154-A | Modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2023-05-26 | — | — | CN | disclosed |