Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324214 | 0.79 | ATR (0.37) | SOS1USP30PDPK1SYK | |
| SCHEMBL30551503 | 0.79 | ATR (0.37) | SOS1USP30PDPK1SYK | |
| SCHEMBL30799692 | 0.77 | AAK1 (0.38) | SOS1SSTR4USP30AAK1BACE1 | |
| SCHEMBL30799352 | 0.77 | SSTR4 (0.35) | SOS1SSTR4USP30 | |
| SCHEMBL2610396 | 0.77 | BACE1 (0.35) | SOS1SSTR4USP30HDAC1HDAC8 | |
| SCHEMBL30397185 | 0.76 | SOS1 (0.37) | SOS1SSTR4USP30HDAC1HDAC8 | |
| SCHEMBL25262847 | 0.76 | SOS1 (0.37) | SOS1SSTR4USP30HDAC1HDAC8 | |
| SCHEMBL1180489 | 0.76 | POLB (0.42) | SOS1USP30BACE1 | |
| SCHEMBL17166912 | 0.76 | SSTR4 (0.36) | SOS1SSTR4USP30HDAC1HDAC8 | |
| SCHEMBL29935256 | 0.76 | POLB (0.42) | SOS1USP30BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853730-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |