SCHEMBL3039736

SCHEMBL3039736

COc1cc(Nc2ccc(S(=O)(=O)N3CCOCC3)c(C(F)(F)F)c2)cc(OC)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 14/20 1.00
CNR1 P21554 6/20 0.62
GSTO1 P78417 1/20 0.48
ALDH1A1 P00352 2/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3039903 0.81 CNR2 (1.00) CNR2CNR1ALDH1A1
SCHEMBL13456195 0.78 CNR2 (0.65) CNR2CNR1
SCHEMBL3040968 0.77 CNR2 (1.00) CNR2CNR1ALDH1A1KMT2A
SCHEMBL3220022 0.77 CNR2 (1.00) CNR2CNR1
SCHEMBL3038867 0.73 CNR2 (1.00) CNR2CNR1
SCHEMBL840799 0.73 CNR2 (0.57) CNR2CNR1GSTO1ALDH1A1KMT2A
SCHEMBL3039136 0.72 CNR2 (1.00) CNR2CNR1
SCHEMBL13456176 0.72 CNR2 (0.90) CNR2CNR1ALDH1A1KMT2A
SCHEMBL13456185 0.72 CNR2 (0.90) CNR2CNR1
SCHEMBL840686 0.71 KMT2A (0.57) CNR2CNR1GSTO1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9422235-B2 Sulfonamide derivatives with therapeutic indications PHARMOS CORPORATION (US) 2016-08-23 US claimed
US-20100056528-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION 2010-03-04 US claimed
EP-2139852-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS Pharmos Corporation (US) 2010-01-06 EP claimed
WO-2008075353-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION (US) 2008-06-26 WO claimed
US-9422235-B2 Sulfonamide derivatives with therapeutic indications PHARMOS CORPORATION (US) 2016-08-23 US disclosed
US-20100056528-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION 2010-03-04 US disclosed
EP-2139852-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS Pharmos Corporation (US) 2010-01-06 EP disclosed
WO-2008075353-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION (US) 2008-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056528-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS SULT2A1, STS, SULT1A1 CNR2 41/4885CNR1 207/4885GSTO1 951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.