Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 5/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25530547 | 1.00 | MAP4K4 (0.49) | MAP4K4PDE10ABTKJAK3MET | |
| SCHEMBL25417601 | 1.00 | MAP4K4 (0.49) | MAP4K4PDE10ABTKJAK3MET | |
| SCHEMBL25529006 | 0.94 | PIM1 (0.48) | MAP4K4PDE10ABTKMETPIM1 | |
| SCHEMBL25238236 | 0.85 | MAP4K4 (0.46) | MAP4K4PDE10ABTKJAK3MET | |
| SCHEMBL25417386 | 0.85 | MAP4K4 (0.46) | MAP4K4PDE10ABTKJAK3MET | |
| SCHEMBL25538214 | 0.84 | BTK (0.52) | MAP4K4PDE10ABTKJAK3CA1 | |
| SCHEMBL25417882 | 0.83 | BTK (0.51) | MAP4K4BTKJAK3METDPP4 | |
| SCHEMBL1976365 | 0.80 | PIM1 (0.57) | MAP4K4PDE10APIM1PIM2 | |
| SCHEMBL1976367 | 0.80 | PIM1 (0.57) | MAP4K4PDE10APIM1PIM2 | |
| SCHEMBL25530656 | 0.78 | KMT2A (0.33) | METPIM1PIM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |