Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25417601 | 0.78 | MAP4K4 (0.49) | KMT2APIM1PIM2MET | |
| SCHEMBL25530547 | 0.78 | MAP4K4 (0.49) | KMT2APIM1PIM2MET | |
| SCHEMBL30397448 | 0.78 | MAP4K4 (0.49) | KMT2APIM1PIM2MET | |
| SCHEMBL25529006 | 0.74 | PIM1 (0.48) | PIM1PIM2MET | |
| SCHEMBL23107339 | 0.72 | MAP4K4 (0.36) | METGPR119 | |
| SCHEMBL20460061 | 0.70 | IRAK1 (0.33) | PIM1PIM2 | |
| SCHEMBL18600085 | 0.69 | GAA (0.46) | KMT2APIM1PIM2HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL25418958 | 0.68 | PIM1 (0.55) | PIM1PIM2IRAK4 | |
| SCHEMBL25530705 | 0.67 | CYP3A4 (0.30) | — | |
| SCHEMBL18600082 | 0.66 | LMNA (0.50) | KMT2AALDH1A1GPR119MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |