Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1311436 | 0.88 | — | — | |
| SCHEMBL22091577 | 0.80 | — | — | |
| SCHEMBL28039313 | 0.75 | — | — | |
| SCHEMBL149854 | 0.69 | TSHR (0.34) | ALDH1A1 | |
| SCHEMBL452179 | 0.67 | TSHR (0.46) | ALDH1A1 | |
| SCHEMBL8890 | 0.64 | TSHR (0.48) | — | |
| SCHEMBL24682 | 0.64 | — | — | |
| SCHEMBL9620890 | 0.64 | TSHR (0.38) | — | |
| SCHEMBL28479766 | 0.63 | — | — | |
| SCHEMBL129579 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192122-B1 | DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF | SHANGHAI INST PHARM INDUSTRY (CN) | 2014-01-01 | — | — | EP | disclosed |
| US-20130005710-A1 | AMINOPYRIDINE DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-03 | — | — | US | disclosed |
| EP-2502909-A1 | AMINOPYRIDINE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-09-26 | — | — | EP | disclosed |
| US-8258176-B2 | Dithiolopyrrolone compounds, the preparation and the use thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2012-09-04 | — | — | US | disclosed |
| US-20100210856-A1 | DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2010-08-19 | — | — | US | disclosed |
| EP-2192122-A1 | DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF | Shanghai Institute of Pharmaceutical Industry (CN) | 2010-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005710-A1 | AMINOPYRIDINE DERIVATIVE | DCX, NR0B1, NR4A1 | ALDH1A1 274/4885 |
| US-20100210856-A1 | DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF | THPO, CD47, QDPR | ALDH1A1 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.