Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 13/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 13/20 | 0.39 |
| ▸ | CDK7 | P50613 | 4/20 | 0.39 |
| ▸ | CCNH | P51946 | 4/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 13/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.39 |
| ▸ | CDK9 | P50750 | 10/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25205550 | 0.83 | ULK1 (0.41) | ULK1CDK2CCNE1CDK1KDR | |
| SCHEMBL31006885 | 0.82 | CCNK (0.56) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25531573 | 0.82 | CCNK (0.56) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25531402 | 0.82 | ULK1 (0.49) | ULK1CCNKCDK12CDK2CCNE1 | |
| SCHEMBL30397492 | 0.82 | ULK1 (0.49) | ULK1CCNKCDK12CDK2CCNE1 | |
| SCHEMBL25522696 | 0.81 | ULK1 (0.55) | ULK1CCNKCDK12CDK7CCNH | |
| SCHEMBL25531460 | 0.81 | ULK1 (0.43) | ULK1CCNKCDK12CDK7CCNH | |
| SCHEMBL25525391 | 0.81 | ULK1 (0.38) | ULK1CCNKCDK12CDK7CCNH | |
| SCHEMBL30397859 | 0.81 | ULK1 (0.42) | ULK1CCNKCDK12CDK7CCNH | |
| SCHEMBL30397476 | 0.81 | ULK1 (0.42) | ULK1CCNKCDK12CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |