Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.64 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NMUR2 | Q9GZQ4 | 2/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | TOP1 | P11387 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30704422 | 0.92 | NTRK1 (0.74) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL11768754 | 0.92 | NTRK1 (0.74) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL23621000 | 0.84 | NTRK1 (0.61) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL22247535 | 0.82 | NTRK1 (0.59) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL1308829 | 0.81 | NTRK1 (0.46) | NTRK1PLK3KDM4EHSD17B10MAOA | |
| SCHEMBL11819311 | 0.78 | NTRK1 (0.46) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL22541365 | 0.77 | NTRK1 (0.55) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL11821359 | 0.75 | PRMT1 (0.50) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL1520211 | 0.75 | NTRK1 (0.56) | NTRK1PLK3KDM4ECYP3A4HSD17B10 | |
| SCHEMBL817788 | 0.74 | CYP3A4 (0.47) | NTRK1PLK3KDM4ECYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12286423-B2 | Antiviral 1,3-di-oxo-indene compounds | NOVARTIS AG (CH) | 2025-04-29 | — | — | US | disclosed |
| US-12083092-B2 | Antiviral 1,3-di-oxo-indene compounds | NOVARTIS AG (CH) | 2024-09-10 | — | — | US | disclosed |
| EP-4139301-A1 | ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS | Novartis AG (CH) | 2023-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12286423-B2 | Antiviral 1,3-di-oxo-indene compounds | IRF3, EIF2AK2, ZC3HAV1 | NTRK1 4799/4885PLK3 2897/4885KDM4E 3114/4885 |
| US-12083092-B2 | Antiviral 1,3-di-oxo-indene compounds | IRF3, EIF2AK2, MAVS | NTRK1 4787/4885PLK3 2478/4885KDM4E 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.