Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276427 | 0.80 | RIPK1 (0.42) | ATRAKT1RIPK1 | |
| SCHEMBL13285783 | 0.77 | RIPK1 (0.38) | RIPK1 | |
| SCHEMBL18952804 | 0.73 | PSEN1 (0.38) | RIPK1 | |
| SCHEMBL21050393 | 0.73 | PSEN1 (0.38) | RIPK1 | |
| SCHEMBL18971164 | 0.73 | PSEN1 (0.38) | RIPK1 | |
| SCHEMBL18971166 | 0.73 | PSEN1 (0.38) | RIPK1 | |
| SCHEMBL18952715 | 0.73 | PSEN1 (0.38) | RIPK1 | |
| SCHEMBL20159585 | 0.70 | PSEN1 (0.34) | RIPK1 | |
| SCHEMBL16578759 | 0.69 | KHK (0.35) | HRH4RIPK1 | |
| SCHEMBL31233519 | 0.69 | ALDH1A1 (0.33) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |