Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213597 | 0.89 | MAPT (0.58) | MAPTLMNAHTTGAAKMT2A | |
| SCHEMBL2189508 | 0.86 | HTT (0.70) | MAPTLMNAHTTGAANR3C1 | |
| SCHEMBL3378810 | 0.83 | NPC1 (0.60) | MAPTLMNA | |
| SCHEMBL302225 | 0.79 | LMNA (0.60) | MAPTLMNAHTTGAAKMT2A | |
| SCHEMBL3377228 | 0.76 | MAPT (0.74) | MAPTLMNAHTTGAAKMT2A | |
| SCHEMBL3376926 | 0.75 | MAPT (0.60) | MAPTLMNAHTTGAANR3C1 | |
| SCHEMBL303030 | 0.75 | GRM2 (0.54) | MAPTLMNAHTTGAAKMT2A | |
| SCHEMBL2185822 | 0.73 | RAB9A (0.59) | MAPTLMNAHTTGAAKMT2A | |
| SCHEMBL301695 | 0.73 | GAA (0.76) | MAPTLMNAHTTGAANR3C1 | |
| SCHEMBL3379839 | 0.73 | LMNA (0.56) | MAPTLMNAKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |