Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 8/20 | 0.64 |
| ▸ | AXL | P30530 | 1/20 | 0.64 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858328 | 1.00 | CDK8 (0.64) | CDK8AXLNUDT1DHFRPIK3CA | |
| SCHEMBL20627463 | 0.88 | ALOX5AP (0.68) | CDK8AXLALOX5APFEN1 | |
| SCHEMBL13854162 | 0.88 | CDK8 (0.56) | CDK8AXLNUDT1DHFRPIK3CA | |
| SCHEMBL13854156 | 0.83 | DHFR (0.56) | CDK8AXLNUDT1DHFRPIK3CA | |
| SCHEMBL15730259 | 0.82 | FEN1 (0.57) | CDK8AXLNUDT1DHFRPIK3CA | |
| SCHEMBL31064990 | 0.81 | CDK8 (0.64) | CDK8AXLNUDT1PIK3CAPIK3CD | |
| SCHEMBL858203 | 0.81 | CDK8 (0.64) | CDK8AXLNUDT1PIK3CAPIK3CD | |
| SCHEMBL858609 | 0.81 | AXL (0.64) | CDK8AXLNUDT1PIK3CAPIK3CD | |
| SCHEMBL12127568 | 0.81 | CDK8 (0.64) | CDK8AXLNUDT1DHFRPIK3CA | |
| SCHEMBL13854545 | 0.81 | DHFR (0.54) | CDK8AXLNUDT1DHFRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | CDK8 485/4885AXL 1433/4885NUDT1 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.