Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 7/20 | 0.57 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.57 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.57 |
| ▸ | CDK8 | P49336 | 4/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135664 | 0.83 | CDK8 (0.61) | NUDT1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL18853774 | 0.83 | FEN1 (0.58) | FEN1ALOX5APNUDT1CDK8AXL | |
| SCHEMBL30399451 | 0.82 | CDK8 (0.64) | FEN1ALOX5APNUDT1CDK8AXL | |
| SCHEMBL858328 | 0.82 | CDK8 (0.64) | FEN1ALOX5APNUDT1CDK8AXL | |
| SCHEMBL15730613 | 0.79 | PIK3CA (0.55) | FEN1ALOX5APNUDT1CDK8AXL | |
| SCHEMBL16135667 | 0.79 | PARP10 (0.54) | FEN1ALOX5APNUDT1CDK8AXL | |
| SCHEMBL13854162 | 0.79 | CDK8 (0.56) | NUDT1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL858609 | 0.79 | AXL (0.64) | FEN1ALOX5APNUDT1CDK8AXL | |
| SCHEMBL945016 | 0.77 | CDK8 (0.60) | FEN1ALOX5APNUDT1CDK8AXL | |
| SCHEMBL15617183 | 0.77 | NUDT1 (0.51) | FEN1ALOX5APNUDT1CDK8AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2017-05-18 | — | — | US | disclosed |
| US-9540343-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | FEN1 2354/4885ALOX5AP 1825/4885NUDT1 113/4885 |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | FEN1 2354/4885ALOX5AP 1825/4885NUDT1 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.