Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 5/20 | 0.39 |
| ▸ | SGK1 | O00141 | 4/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26176370 | 1.00 | MAPK1 (0.43) | MAPK1AXLSGK1CAMKK2JAK1 | |
| SCHEMBL30399669 | 0.86 | DYRK1A (0.45) | MAPK1AXLJAK1NAMPTJAK2 | |
| SCHEMBL26176371 | 0.86 | DYRK1A (0.45) | MAPK1AXLJAK1NAMPTJAK2 | |
| SCHEMBL30399129 | 0.80 | MAP3K11 (0.53) | ACACBACACAMAP3K11 | |
| SCHEMBL26174983 | 0.80 | MAP3K11 (0.53) | ACACBACACAMAP3K11 | |
| SCHEMBL26176386 | 0.78 | JAK1 (0.39) | MAPK1JAK1NAMPTPKMDYRK1A | |
| SCHEMBL30400429 | 0.78 | JAK1 (0.39) | MAPK1JAK1NAMPTPKMDYRK1A | |
| SCHEMBL26174982 | 0.76 | MAP3K11 (0.51) | ACACBACACAMAP3K11 | |
| SCHEMBL30400509 | 0.76 | MAP3K11 (0.51) | ACACBACACAMAP3K11 | |
| SCHEMBL30399632 | 0.76 | EGLN1 (0.43) | MAP3K11CLK1DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |