Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 6/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26176386 | 1.00 | JAK1 (0.39) | JAK1DYRK2NAMPTROCK2GPR119 | |
| SCHEMBL26176177 | 0.89 | HTR1A (0.42) | HTR1AHTR1DHTR1BHTR1FCDC7 | |
| SCHEMBL30399856 | 0.89 | HTR1A (0.42) | HTR1AHTR1DHTR1BHTR1FCDC7 | |
| SCHEMBL25263374 | 0.85 | MAPKAPK2 (0.42) | HTR1AHTR1DHTR1BHTR1FMAPK1 | |
| SCHEMBL30398369 | 0.85 | MAPKAPK2 (0.42) | HTR1AHTR1DHTR1BHTR1FMAPK1 | |
| SCHEMBL30400627 | 0.78 | MAPK1 (0.43) | JAK1NAMPTROCK2MAPK1PKM | |
| SCHEMBL26176370 | 0.78 | MAPK1 (0.43) | JAK1NAMPTROCK2MAPK1PKM | |
| SCHEMBL26176371 | 0.77 | DYRK1A (0.45) | JAK1DYRK2NAMPTROCK2HDAC1 | |
| SCHEMBL30399669 | 0.77 | DYRK1A (0.45) | JAK1DYRK2NAMPTROCK2HDAC1 | |
| SCHEMBL30399299 | 0.76 | DYRK1A (0.42) | JAK1HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |