Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26176373 | 1.00 | USP30 (0.44) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL29964244 | 0.80 | KMT2A (0.52) | USP30GPR119HDAC1HDAC8HDAC6 | |
| SCHEMBL742173 | 0.80 | KMT2A (0.52) | USP30GPR119HDAC1HDAC8HDAC6 | |
| SCHEMBL26023997 | 0.80 | USP30 (0.44) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL31693862 | 0.80 | HDAC2 (0.43) | USP30BUB1PDK2GPR119HDAC1 | |
| SCHEMBL31694099 | 0.80 | ALK (0.42) | USP30BACE1BUB1PDK2GPR119 | |
| SCHEMBL2187569 | 0.80 | MEN1 (0.46) | USP30BUB1PDK2GPR119HDAC1 | |
| SCHEMBL30623425 | 0.80 | MEN1 (0.46) | USP30BUB1PDK2GPR119HDAC1 | |
| SCHEMBL26176388 | 0.80 | ALK (0.42) | USP30BACE1BUB1PDK2GPR119 | |
| SCHEMBL30935054 | 0.78 | USP30 (0.41) | USP30PRMT5WDR77BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |