Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | STS | P08842 | 4/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623425 | 1.00 | MEN1 (0.46) | MEN1KMT2ASTSUSP30ESR2 | |
| SCHEMBL17205567 | 0.93 | USP30 (0.48) | MEN1KMT2ASTSUSP30ESR2 | |
| SCHEMBL2189176 | 0.91 | MEN1 (0.46) | MEN1KMT2ASTSUSP30ESR2 | |
| SCHEMBL25355455 | 0.87 | MEN1 (0.43) | MEN1KMT2ASTSUSP30ESR2 | |
| SCHEMBL31693862 | 0.86 | HDAC2 (0.43) | MEN1KMT2AUSP30PDK2HDAC1 | |
| SCHEMBL26176388 | 0.86 | ALK (0.42) | USP30ESR2PDK2HDAC1HDAC8 | |
| SCHEMBL31694099 | 0.86 | ALK (0.42) | USP30ESR2PDK2HDAC1HDAC8 | |
| SCHEMBL26016812 | 0.85 | ALDH1A1 (0.38) | MEN1KMT2ASTSUSP30BUB1 | |
| SCHEMBL30623350 | 0.85 | ALDH1A1 (0.38) | MEN1KMT2ASTSUSP30BUB1 | |
| SCHEMBL1221984 | 0.83 | HRH3 (0.51) | USP30PDK2HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250195483-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMA (US) | 2025-06-19 | — | — | US | disclosed |
| EP-4476207-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | SYNGENTA CROP PROTECTION LLC | 2014-01-30 | — | — | US | disclosed |
| US-8354423-B2 | Insecticidal spironindane derivatives | SYNGENTA CROP PROTECTION LLC (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1697327-B1 | INSECTICIDAL SPIROINDANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1697327-A1 | INSECTICIDAL SPIROINDANE DERIVATIVES | Syngenta Participations AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058836-A1 | INSECTICIDAL SPIROINDANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250195483-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, PNLIP, SAAL1 | MEN1 2419/4885KMT2A 4614/4885STS 957/4885 |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | NR1D1, NR1D2, NR1I3 | MEN1 1169/4885KMT2A 2041/4885STS 1246/4885 |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | NR1D1, NR1D2, NR1I3 | MEN1 1169/4885KMT2A 2041/4885STS 1246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.