Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935277 | 0.91 | USP30 (0.40) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL30935187 | 0.81 | RORC (0.41) | USP30BACE1GPR119NR1H2DDB1 | |
| SCHEMBL12078031 | 0.79 | BACE1 (0.38) | PRMT5WDR77BACE1ROCK1 | |
| SCHEMBL30400992 | 0.78 | USP30 (0.44) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL26176373 | 0.78 | USP30 (0.44) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL30935109 | 0.77 | BACE1 (0.35) | PRMT5WDR77BACE1ROCK1 | |
| SCHEMBL30935204 | 0.77 | BACE1 (0.37) | PRMT5WDR77BACE1 | |
| SCHEMBL30935124 | 0.75 | BACE1 (0.36) | PRMT5WDR77BACE1BACE2ROCK1 | |
| SCHEMBL12280372 | 0.74 | USP30 (0.43) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL12078315 | 0.74 | CDC7 (0.39) | PRMT5WDR77BACE1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |