Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.43 |
| ▸ | UCHL5 | Q9Y5K5 | 2/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20401237 | 1.00 | ADORA2A (0.46) | ADORA2AADORA1ADORA2BUCHL5UCHL1 | |
| SCHEMBL20436457 | 0.93 | ADORA2A (0.45) | ADORA2AADORA1ADORA2B | |
| SCHEMBL20400874 | 0.90 | ADORA2A (0.52) | ADORA2AADORA1ADORA2B | |
| SCHEMBL20401627 | 0.88 | ADORA2A (0.47) | ADORA2AADORA1ADORA2BUCHL5UCHL1 | |
| SCHEMBL20436717 | 0.86 | ADORA2A (0.51) | ADORA2AADORA1ADORA2B | |
| SCHEMBL20400588 | 0.85 | UCHL5 (0.55) | ADORA2AADORA1ADORA2BUCHL5UCHL1 | |
| SCHEMBL30400781 | 0.85 | UCHL5 (0.55) | ADORA2AADORA1ADORA2BUCHL5UCHL1 | |
| SCHEMBL20416872 | 0.85 | ADORA2A (0.49) | ADORA2AADORA1ADORA2B | |
| SCHEMBL30401864 | 0.83 | ADORA2A (0.55) | ADORA2AADORA1ADORA2B | |
| SCHEMBL20400722 | 0.83 | ADORA2A (0.55) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768859-A | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-110214012-B | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-05-09 | — | — | CN | disclosed |