UCHL5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21856896	0.48	6/20
SCHEMBL30268029	0.48	6/20
SCHEMBL22545613	0.46	6/20
SCHEMBL29549197	0.46	6/20
SCHEMBL13555506	0.82	5/20
SCHEMBL13734665	0.58	5/20
SCHEMBL25215900	0.56	5/20
SCHEMBL30425196	0.56	5/20
SCHEMBL20914488	0.50	5/20
SCHEMBL20914549	0.50	5/20
SCHEMBL2726830	0.61	4/20
SCHEMBL1986297	0.41	4/20
SCHEMBL21817379	0.35	4/20
SCHEMBL14798452	0.59	3/20
SCHEMBL14798453	0.59	3/20
SCHEMBL17873942	0.59	3/20
SCHEMBL29354956	0.59	3/20
SCHEMBL14233963	0.58	3/20
SCHEMBL17885186	0.55	3/20
SCHEMBL20400588	0.55	3/20

Clinical trials — most relevant to UCHL5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study	PHASE2	WITHDRAWN
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Blood-Based Molecular Clock Biomarkers Predict Acute Ischemic Stroke Onset: A Prospective Observational Study	nan	ACTIVE_NOT_RECRUITING
Evaluation of Biomarker Kinetics After Mild Brain Injury Trauma	nan	COMPLETED
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery	nan	UNKNOWN
Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With Neuroblastoma	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Systemic Biomarkers of Brain Injury From Hyperammonemia	nan	RECRUITING
Cerebral Protection in Aortic Arch Surgery	nan	ACTIVE_NOT_RECRUITING
Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer's Disease	nan	COMPLETED
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries	nan	RECRUITING
Neuronal and Glial Biomarkers in Stroke	nan	COMPLETED
Single-center Transversal Observational Study on the Evaluation of S100B Changes in Subjects Attending the Emergency Department With Head Trauma	nan	RECRUITING
Prediction of Delayed Cognitive Impairment in Cardiac Arrest Survivors With Good Neurological Outcomes	nan	ENROLLING_BY_INVITATION
Blood-based Biomarkers for the Prognosis of Sports Related Concussion	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
VIDAS® TBI Real Life Performance in Subjects With Mild Traumatic Brain Injury (mTBI)	nan	COMPLETED
Use of Cerebral Biomarkers in Minor Traumatic Brain Injury in the Emergency Unit	nan	UNKNOWN
Using Routine Inflammatory and Metabolic Blood Tests (Bedside Included) to Predict Brain Injury in Children After Minor Head Trauma	nan	NOT_YET_RECRUITING
Clinical Trial of Levodopa/Carbidopa ( Sinemet) Therapy in Angel Man Syndrome	nan	COMPLETED
Validating a Blood Test for the Detection of Traumatic Brain Injury in Children	nan	RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Usefulness of Biomarkers in the Management of Mild Traumatic Brain Injury in Adults (Biotraumap)	nan	COMPLETED
Neuronal Damage In Delirium Study	nan	COMPLETED
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
A Study of Biomarkers of Mild Traumatic BRAIN Injury	nan	COMPLETED
BRAINI-2 Elderly Mild TBI European Study	nan	COMPLETED
Biological Markers in Parkinson's Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a UCHL5 binder may also engage these)

Protein	Name	Similarity
Q9XSJ0	—	1.000	Q9XSJ0 →
Q9WUP7	—	1.000	Q9WUP7 →
Q06AT3	—	1.000	Q06AT3 →
O04482	—	0.962	O04482 →
DHX9	ATP-dependent RNA helicase A	0.950	landscape →
Q5R874	—	0.944	Q5R874 →
O70133	—	0.943	O70133 →
Q6NRT5	—	0.943	Q6NRT5 →
Q5R761	—	0.940	Q5R761 →
AP2A2	AP-2 complex subunit alpha-2	0.940	landscape →
Q28141	—	0.940	Q28141 →
P17427	—	0.940	P17427 →
USP39	Ubiquitin carboxyl-terminal hydrolase 39	0.940	landscape →
Q32L19	—	0.940	Q32L19 →
GPS1	COP9 signalosome complex subunit 1	0.939	landscape →
P18484	—	0.939	P18484 →
Q3TIX9	—	0.939	Q3TIX9 →
Q3TXS7	—	0.939	Q3TXS7 →
Q3SZA0	—	0.939	Q3SZA0 →
Q5R648	—	0.938	Q5R648 →
Q9UPY8	—	0.937	Q9UPY8 →
Q99LD4	—	0.937	Q99LD4 →
Q6PER3	—	0.937	Q6PER3 →
PSMD1	26S proteasome non-ATPase regulatory subunit 1	0.937	landscape →
O88544	—	0.937	O88544 →
Q66H80	—	0.937	Q66H80 →
Q9BWT6	—	0.936	Q9BWT6 →
Q5F418	—	0.936	Q5F418 →
Q00981	—	0.936	Q00981 →
Q5XIT1	—	0.935	Q5XIT1 →