Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | NPC1 | O15118 | 4/20 | 0.73 |
| ▸ | RAB9A | P51151 | 4/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 14/20 | 0.72 |
| ▸ | POLB | P06746 | 6/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.66 |
| ▸ | PPARG | P37231 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17544225 | 1.00 | KDM4E (0.81) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL19428461 | 0.90 | KDM4E (0.81) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL2246354 | 0.90 | MAPT (0.81) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL2248459 | 0.90 | KDM4E (1.00) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL30401774 | 0.87 | MAPT (0.82) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL17544315 | 0.87 | MAPT (0.82) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL2248127 | 0.86 | KDM4E (0.89) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL2245338 | 0.86 | MAPT (0.88) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL17544371 | 0.85 | MAPT (0.77) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL30402229 | 0.85 | MAPT (0.77) | KDM4ENPSR1HSD17B10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12258355-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2025-03-25 | — | — | US | disclosed |
| CN-116655618-A | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| US-20230212190-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2023-07-06 | — | — | US | disclosed |
| CN-107108534-B | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212190-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | KDM4E 4585/4885NPSR1 885/4885HSD17B10 966/4885 |
| US-12258355-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | KDM4E 4585/4885NPSR1 885/4885HSD17B10 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.